CRCT · 57 adults with mild to moderate GAD, 8 weeks

A randomized, double-blind, placebo-controlled trial of oral Matricaria recutita (chamomile) extract therapy for generalized anxiety disorder

JD Amsterdam, Y Li, I Soeller, K Rockwell, JJ Mao, J Shults. Journal of Clinical Psychopharmacology. 2009.

Published 2026-10-15Sources checked 2026-10-151 sourceEverstack research teamHow we work

In plain language: Chamomile extract standardized to 1.2% apigenin, 220 to 1,100 mg a day, lowered anxiety scores more than placebo, a modest effect (P = 0.047).
Limits: Small, NIH-funded trial in a disorder population; at most about 13 mg of apigenin a day.
Source: doi.org/10.1097/JCP.0b013e3181ac935c · PubMed 19593179

Summary written by Everstack from the published abstract. Verified against Crossref on 2026-10-15. The authors do not endorse Everstack.