DMechanistic study · Cells and obese mice

Flavonoid apigenin is an inhibitor of the NAD+ase CD38: implications for cellular NAD+ metabolism, protein acetylation, and treatment of metabolic syndrome

C Escande, V Nin, NL Price, V Capellini, AP Gomes, MT Barbosa et al.. Diabetes. 2013.

Published 2026-10-15Sources checked 2026-10-151 sourceEverstack research teamHow we work

In plain language: Apigenin blocked the NAD+-consuming enzyme CD38 and raised NAD+ levels in cells and obese mice. This is the basis of the popular apigenin and NAD+ idea.
Limits: No human data; does not test sleep.
Source: doi.org/10.2337/db12-1139 · PubMed 23172919

Summary written by Everstack from the published abstract. Verified against Crossref on 2026-10-15. The authors do not endorse Everstack.