Research library / Resveratrol and sirtuins

SRT1720, SRT2183, SRT1460, and Resveratrol Are Not Direct Activators of SIRT1

M Pacholec, J Bleasdale, B Chrunyk, D Cunningham, D Flynn, R Garofalo et al.. Journal of Biological Chemistry. 2010.

Published 2026-10-15Sources checked 2026-10-151 sourceEverstack research teamHow we work

In plain language

Pfizer scientists reported resveratrol and SRT compounds are not direct SIRT1 activators with native substrates.

Limits

Lab assays; competing commercial interests.

Source

doi.org/10.1074/jbc.M109.088682 · PubMed 20061378 · Free full text

Summary written by Everstack from the published abstract. Verified against Crossref on 2026-10-15. The authors do not endorse Everstack.