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Epigenetic clocks: measuring 'biological age'

Well-validated as age estimators; uncertain as proof that an intervention slows aging.

Published Sources checked 1 sourceEverstack research teamHow we work

Human chromosomes (grey) with telomeres lit at their tips (white)
Human chromosomes (grey) with telomeres lit at their tips (white). Image: U.S. Department of Energy Human Genome Program, Public domain

Editorial section. Research summaries are not product claims and contain no product links or offers. A summary is never proof that any product works.

The question
What do DNA methylation clocks measure, and can they judge a supplement?
Study design
Development of a multi-tissue DNA methylation age predictor from thousands of samples (2013). [1]
What they found
Methylation at 353 sites predicted chronological age accurately across most tissues. Later clocks were trained to predict health outcomes. [1]
Limitations
Consumer tests vary in reliability, and a lower score after an intervention is not proven to mean a longer or healthier life.
What this does not mean
We will not claim that any product lowers your biological age.
Sources
  1. Horvath S. Genome Biol. 2013;14:R115. doi.org/10.1186/gb-2013-14-10-r115

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